| 摘要 |
It is described a process for the synthesis of optically active anthracyclines characterised by the fact that the key intermediate (R)2-acetyl-2-hydroxy- 1,2,3,4-tetrahydronaphtalene 5,8-dialkoxy is prepared from 5,8-dialcoxy-3,4- dihydronaphtalene by acylation asymmetric dihydroxylation, transformation into chloroacetate, dehydrochloridation and final hydrolysis.
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