发明名称 |
A NEW ASSAY FOR THE DETECTION AND QUANTITATION OF HEMIMETHYLATION |
摘要 |
There is disclosed a method to measure the fraction of DNA molecules that ishemi-methylated at a specific CpG dinucleotide in a particular DNA sequence, in a pool of DNA molecules having mixed DNA methylation states at said CpG dinucleotide. There is also disclosed methods to calculate the rates of de novo-, and maintenance-methylation per cell division that occur at said CpG dinucleotide. Additionally, there is disclosed methylation kits for use in measuring and quantitating hemi-methylation, and for calculating the rates of de novo-, and maintenance-methylation.
|
申请公布号 |
CA2428245(A1) |
申请公布日期 |
2002.05.16 |
申请号 |
CA20012428245 |
申请日期 |
2001.11.08 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
JONES, PETER A.;TOMIGAHARA, YASHITAKA;LAIRD, PETER W.;LIANG, GANGNING |
分类号 |
G01N33/50;C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|