PEPTIDES THAT SELECTIVELY BIND TO EXPANDED POLYGLUTAMINE REPEAT DOMAINS AND METHODS OF USE THEREOF
摘要
Compounds that selectively bind to expanded polyglutamine repeats are disclosed. Such compounds are characterized in that they bind to a first polyglutamine peptide consisting of 60 glutamine residues under conditions in which they do not bind to a second polyglutamine peptide consisting of 20 glutamine residues. Conjugates of such compounds, nucleic acids encoding the same, and methods of use thereof are also disclosed.
申请公布号
WO0168678(A3)
申请公布日期
2002.05.16
申请号
WO2001US08222
申请日期
2001.03.14
申请人
DUKE UNIVERSITY;STRITTMATTER, WARREN, J.;BURKE, JAMES, R.;NAGAI, YOSHITAKA