| 摘要 |
<p>Preparation of oxetan-2-one derivatives of formula (I) comprises reaction of an ester of formula (II) with an enol ether (III) to give an acetal of formula (IV), reducing (IV) to give an aldehyde of formula (V) and reacting (V) with diisobutylaluminium hydride and a metal enolate (VI) to give (I). R1 = 1-20C alkyl, alkenyl, alkadienyl or alkynyl (all optionally mono-, di- or trisubstituted by halo, alkyl or aryl or interrupted by O, S or 1,4-arylene); R2 = R1, arylamino, alkoxy, aryloxy, alkylsulphonyl, arylsulphonyl or halo; R3, R4 = alkyl (preferably methyl or ethyl); R5 = alkyl (preferably methyl or ethyl); and R6 = alkylidene (preferably methylidene or ethylidene); or R5+R6 = 4-15C alkylidene. (IV) and (V) are claimed per se.</p> |
