发明名称 |
HEXAHYDROPYRROLO¬1,2-C PYRIMIDINES AS ANTIVIRAL, ANTIFUNGAL AND/OR ANTITUMOR AGENTS |
摘要 |
<p>Improved methods for convergent, total enantioselective synthesis of guanidinium alkaloid compounds including ones having cis- or -trans-1-oxo-and 1-iminohexahydropyrrolo [1,2c]pyrimidine units including, 13,14,15-isocrambescidin 800, crambescidin 800 and ptilomycalin A, for use as therapeutic agents having antifungal and/or antiviral and/or antitumor activity are provided. Methods for preparing novel pentacyclic intermediates for the preparation of the crambescidin/ptilomycalin family of guanidinium alkaloids and congeners are also disclosed.</p> |
申请公布号 |
EP1204666(A1) |
申请公布日期 |
2002.05.15 |
申请号 |
EP20000947033 |
申请日期 |
2000.06.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
OVERMAN, LARRY, A.;STAPPENBECK, FRANK;MCDONALD, ANDREW, I. |
分类号 |
A61K31/527;A61P31/10;A61P31/12;A61P35/00;C07D491/22;(IPC1-7):C07D491/22;A61K31/505 |
主分类号 |
A61K31/527 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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