发明名称 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
摘要 |
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product is stable and proteolytically active. Methods of using the products of the invention are described. |
申请公布号 |
AU2888702(A) |
申请公布日期 |
2002.05.15 |
申请号 |
AU20020028887 |
申请日期 |
2001.11.06 |
申请人 |
UNITED STATES ARMY MEDICAL RESEARCH AND MATERIAL COMMAND |
发明人 |
LEONARD A. SMITH;MELODY JENSEN |
分类号 |
C12N9/64 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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