CRYSTALLINE POLYMORPH OF A BISULFATE SALT OF A THROMBIN RECEPTOR ANTAGONIST

摘要

A CRYSTALLINE POLYMORPH OF A BISLULFATE SALT OF A THROMBIN RECEPTOR ANTAGONIST COMPOUND, WHICH EXHIBITS A POWDER X-RAY DIFFRACTION PROFILE SUBSTANTIALLY THE SAME AS THAT SHOWN IN 1, OR WHICH EXHIBITS A DIFFERENTIAL SCANNING CALORIMTERY PROFILE SUBSTANTIALLY THE SAME AS THAT SHOWN IN 3, AND IS REPRESENTED BY THE FORMULA FOR COMPOUND 2: AND PROCESSES FOR PREPARING COMPOUND 2 ARE DISCLOSED. PHARMACEUTICAL COMPOSITIONS COMPRISING THE POLYMORPH OF THE BISULFATE SALT AND AT LEAST ONE EXCIPIENT OR CARRIER, AND METHODS OF USING THE POLYMORPH OF COMPOUND 2 TO TREAT A VARIETY OF PHYSIOLOGICAL DISORDERS, SUCH AS THROMBOSIS, ARE ALSO DISCLOSED.