PROCESS FOR DUST-FREE ENZYME MANUFACTURE

摘要

This invention relates to processes for manufacture of substantially dust-fr ee particles of enzymes by spray-coating solid particulate cores or seeds with fermentation broths containing enzymes. Fermentation broths containing from 5 % to 100 % total solids as enzyme and 4 % - 55 % total solids content in the broth may be use d. For broths containing 4 % - 31 % total solids, en- zyme and coating agents may be spray-coated so as to achieve a weight gain o f 1 % - 24 % w/w aver the initial weight of the cores. For broths with 31 % - 55 % total solids; a corresponding weight gain of 1 % - 100 % may be achieved. The enzyme coated cores may be further coated with coating agents: The total dry weight added to the cores ranges from 1 % to 19 % in the absence of coat- ing agents and 1 % to 24 % in the presence of coating agents when the lower range of total solids content is used. The fatal dry weight added to the cares ranges from 1 % to 100 % when the higher range of total solids content is used. These conditions are especially useful in the granulation of enzymes with very high specific activities, so that effective enzyme activity can be provided by adding low amounts of broth solids to the cores. Reduction in added solid s is of significant economic benefit in reducing gran- ulation costs.