| 摘要 |
<p>The invention provides a Gene Highly Expressed in Prostate ('GHEP'). The gene is found in normal and neoplastic prostate, and encodes two short proteins, one 34 amino acids ('ghep34') in length and one 35 amino acids in length ('ghep35'). Detection of the transcript or of the proteins in tissues other than the prostate, liver, or salivary gland is indicative of prostate cancer. The nucleic acids, proteins, and immunogenic fragments thereof can be used to raise an immune response to prostate cancer. The invention further provides methods of detecting the proteins or the gene transcript in a biological sample. If the biological sample is from a tissue other than the prostate, liver or salivary gland, detection of either of the protein or of the gene transcript is indicative of the presence of prostate cancer in the subject from whom the sample was taken. The invention further provides antibodies which specifically recognize ghep34 and antibodies which specifically recognize ghep35, as well as kits for the detection of one or both of the proteins in a sample.</p> |
