COMPOSITION CONTAINING FIXED DOSE OF ANGIOTENSIN-TRANSFORMING ENZYME AND CALCIUM CANAL ANTAGONIST AND METHOD FOR PRODUCING THE COMPOSITION AND TREATING CARDIOVASCULAR DISEASES

摘要

medicine. SUBSTANCE: composition has Enalapryl dose or its pharmaceutically permissible salt and different dose of Nitrenedipine or its pharmaceutically permissible salt. The composition is administered in single dose as galenic preparation. Method involves a) dissolving Enalapryl maleate in water with organic salt; b) mixing microionized Nitrenedipine with loosening fillers fraction, moistening agents, fragmental diluting agent, gluing agent and plastic diluting agent preliminarily sieved; c) granulating products homogenized at (b) stage with solution produced at (a); d) drying the granulated mass; e) introducing lubricating agent and the rest of the loosening fillers fraction and homogenizing the calibrated granulate; f) pressing the granulate. EFFECT: enhanced effectiveness of treatment; reduced risk of adverse side effects. 10 cl, 3 dwg, 8 tbl