| 摘要 |
<p>A composition and methods thereof for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as metformin, on a once-a-day basis. The dosage form provides a mean time to maximum plasma concentration (Tmax) of the drug which occurs at 5.5 to 7.5 hours after oral administration on a one-a-day basis to human patients. Preferably, the dose of drug is administered at dinnertime to a patient in the fed state.</p> |
