摘要 |
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ("PQS") molecules, <i>e.g</i>., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signalling in bacteria using the compounds of the invention are also described. |
申请人 |
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;UNIVERSITY OF ROCHESTER;EAST CAROLINA UNIVERSITY;PESCI, EVERETT, C;MILBANK, JARED, B, J;PEARSON, JAMES, P.;KENDE, ANDREW, S.;GREENBERG, EVERETT, PETER;IGLEWSKI, BARBARA, H. |
发明人 |
PESCI, EVERETT, C;MILBANK, JARED, B, J;PEARSON, JAMES, P.;KENDE, ANDREW, S.;GREENBERG, EVERETT, PETER;IGLEWSKI, BARBARA, H. |