ETS-TRANSCRIPTION FACTOR RELATED COMPOUND SPECIFIC PROMOTER AND TRANSACTIVATORS THEREOF

摘要

The present invention relates to novel means for the treatment of diseases, in particular muscular diseases. The present invention relates to a nucleic acid capable of controlling the expression of a heterologous gene and of being selectively activated by an Ets-transcription factor related compound. The invention further relates to constructs, host cells comprising said nucleic acid, methods for recombinant expression of heterologous genes and methods for screening and identifying of candidate compounds having transcription regulatory activity using them. The invention additionally relates to a fusion protein for specifically activating said nucleic acid. The invention also relates to a kit comprising the nucleic acid and the fusion protein for recombinant expression of a heterologous gene.