| 摘要 |
organic chemistry, steroids, pharmacy. SUBSTANCE: invention relates to steroid compound of the general formula (I) where means =O, -OH, OR or OOCR where R means alkyl group with from 1 to 6 carbon atoms; R6 means H or where m = 1 or 2; R7 means H, C1-4- alkyl, C2-4- alkenyl or C2-4- alkynyl; R11 means H, C1-4- alkyl, C2-4- alkenyl, C2-4- alkynyl; E means (with exception of carbon atoms 16 and 17 of ring D) 4-7-membered hydrocarbon ring where indicated ring is at alpha- position with respect to ring D substituted with the group RE, and comprises optionally one endocyclic double bond; RE means H, C1-5 alkyl, C2-5- alkenyl, C2-5- alkynyl, C1-5- alkylidene, -(CH2)n-N3 or -(CH2)n where n = 1 or 2 and where alkyl group can be substituted for OR, -OOCR where R is alkyl with 1-6 carbon atoms; R17 means OH, -OR or OOCR where R means alkyl with 1-6 carbon atoms where indicated steroid compound can involve but optionally a single double bond, DELTA5(10), DELTA4(5) either ring A can be aromatic. The invention relates to also a pharmaceutical composition comprising the indicated steroid compound. Steroid compounds of the invention shows very high effectiveness for prophylaxis or treatment of disorders associated with per- or post menopause and, more preferably, for prophylaxis or treatment of osteoporosis. Except for, steroid compounds of the invention can be used as contraceptive agents. EFFECT: improved method of synthesis, valuable medicinal properties of steroid compound. 10 cl, 1 tbl, 8 ex |
