发明名称 |
Heterocycles useful in the treatment of benign prostatic hyperplasia |
摘要 |
This invention relates a to a series of heterocyclic substituted piperazines of Formula Ipharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the alpha-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
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申请公布号 |
US6384035(B1) |
申请公布日期 |
2002.05.07 |
申请号 |
US19980169571 |
申请日期 |
1998.10.09 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
HUTCHINGS RICHARD H.;KHATUYA HARIPADA;KUO GEE-HONG;LI XIAOBING;MURRAY WILLIAM V.;PROUTY CATHERINE;VILLANI FRANK;YIM NELSON C. F.;MARYANOFF CYNTHIA |
分类号 |
C07D295/08;A61K31/495;A61K31/496;A61K31/506;A61P13/08;A61P43/00;C07D211/76;C07D213/38;C07D261/08;C07D263/32;C07D263/34;C07D277/20;C07D277/28;C07D277/56;C07D295/10;C07D295/108;C07D295/12;C07D295/13;C07D333/20;C07D333/22;C07D333/28;C07D401/06;C07D409/06;C07D413/06;C07D417/06;(IPC1-7):A01N43/00;A01N43/58;C07D205/08;C07D405/00;C07D241/04 |
主分类号 |
C07D295/08 |
代理机构 |
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地址 |
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