发明名称 |
Process for the synthesis of alkoxyalkyl (trifluormethylphenyl) methanones |
摘要 |
A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.
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申请公布号 |
US6380436(B1) |
申请公布日期 |
2002.04.30 |
申请号 |
US20010700292 |
申请日期 |
2001.02.23 |
申请人 |
SUN PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
THENNATI RAJAMANNAR;DEO KESHAV;MIDHA AJAY SOHANLAL;CHANDRA TILAK;PATEL VIJAY MULJIHHAI |
分类号 |
C07C45/00;C07C49/84;(IPC1-7):C07C45/44;C07C45/46;C07C49/76 |
主分类号 |
C07C45/00 |
代理机构 |
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代理人 |
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地址 |
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