发明名称 |
Isocitrate dehydrogenase, gene thereof, and use of the same in the treatment of obesity, hyperlipidemia, and fatty liver in lipid biosynthesis |
摘要 |
The present invention relates to a cytosolic isocitrate dehydrogenase, its gene, and its use in the treatment of obesity, hyperlipidemia, and fatty liver. The expression of the IDPc gene and the concomitant increase in IDPc level bring about an increase in the cellular level of NADPH, which causes the lipid deposition in adipocytes, leading to obesity and fatty liver. A decrease in the cellular level of NADPH, resulting from the suppression of the gene expression of IDPc, has the effect of inhibiting the lipid deposition in adipocytes. Further, by taking advantage of the suppressive or inhibitory effects of isocitrate dehydrogenase inhibitors, pharmaceutically effective materials for the prophylaxis and treatment of obesity, hyperlipidemia and fatty liver can be developed. |
申请公布号 |
AU7283101(A) |
申请公布日期 |
2002.04.29 |
申请号 |
AU20010072831 |
申请日期 |
2001.07.26 |
申请人 |
TG BIOTECH, INC.;TAE-LIN HUH |
发明人 |
TAE-LIN HUH;HO-JIN KOH;MYUNG-SOOK CHOI;UN-JU JUNG |
分类号 |
A01K67/02;A01K67/027;A61K38/00;A61K38/43;A61K38/44;A61K45/00;A61K48/00;A61P3/04;A61P3/06;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/04;C12N9/99;C12N15/09;C12N15/53;C12N15/63;C12Q1/02;C12Q1/32;C12Q1/60;G01N33/15;G01N33/50 |
主分类号 |
A01K67/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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