| 摘要 |
PURPOSE: A use of a cyclic guanosine 3',5'-monophosphate phosphodiesterase type 5(cGMP PDE V) inhibitor is provided. Therefore, the medicine can treat women with a history of recurrent or habitual spontaneous abortion or premature birth and prevent this state and then may be useful for treatment of disease related with low-level progesterone. CONSTITUTION: The cyclic guanosine 3',5'-monophosphate phosphodiesterase type 5(cGMP PDE V) inhibitor is effectively used for increasing fecundity in a mammal by one or more of (a) promoting the growth of an oocyte, zygote, blastocyst, embryo and/or foetus, (b) increasing the rate or probability of survival of an embryo and/or foetus, and (c) increasing the birth weight of a progeny, and increasing milk productivity.
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