| 摘要 |
<p>The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), R1 is H, OH, OMe, O-(C¿1?-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or null and R?2¿ is H or OH, or R1, R2 form together -O-, R3=R4=OMe or R?3 and R4¿ form together -OCH¿2?O-, R is H, C1-C30alkyl or O-protecting group and R?6¿ represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R6 form together -CMe¿2-?, n is 0 to 8, R?5¿ is H, OH, OMe, O-(C¿1?-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or O-aryl, the doted line is null or forms a double bond depending on the meaning of R?1¿. It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.</p> |
