| 摘要 |
<p>An economical and expedient method is disclosed for the preparation of .alph a.- hydroxy-carboxylic acids or salts thereof in very high enantiomeric purity which comprises oxidizing a corresponding .alpha.-amino-carboxylic acid or salt thereof using an amino acid deaminase followed by reducing the corresponding .alpha.-keto-carboxylic acid or salt produced using a D- or L- lactate dehydrogenase in the combination with an electron donor and an enzyme/substrate system for recycling the electron donor. The resulting .alpha.-hydroxy-carboxylic acids, hydrates, and salts thereof are valuable components and intermediates in the preparation of chiral compounds, especially pharmaceuticals. This invention also relates to the use of .alpha .- amino-carboxylic acids, hydrates, and salts thereof and a coupled enzyme system in the production of .alpha.-hydroxy-carboxylic acids, hydrates, and salts thereof.</p> |
