POLY beta 2 KNOCKOUT ANIMALS

摘要

Genetically modified animals, in which one or both of the gene pair of polyss gene are inactivated, are successfully constructed by establishing ES cells in which one of the gene loci is inactivated by using the gene targeting method, constructing chimeric mice by using these cells, and mating the thus obtained chimeric mice. These knockout mice are characterized by suffering from hypocephalus, hypoplasis, visceral inversion, spermatozoal maturity failure and cilia structural failure in pili in ependymal cells and tracheal epithelial cells (dynein inner-arm missing).