FLAVAN COMPOUNDS, THEIR PREPARATION AND THEIR USE IN THERAPY

摘要

The present invention provides compounds, their preparation and their use in therapy, particularly the treatment of bacterial infection, of the formula (I) wherein p is selected from 4, 5 and 6; q is selected from 3, 4 and 5; each T is the same or different and is selected from -X- and -CR1 2-; each R1 may be the same or different and is selected from H, C¿1-12? alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl and C4-18 aralkyl; each X may be the same or different and is selected from -CR?1 ¿2-, O, S, and NR' where each R' may be the same or different and is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-12 alkynyl, C3-10 aryl, C4-12 aralkyl, C(O)R'', SO2R'' and C(O)NR''2 wherein R'' is selected from C1-6 alkyl, C2-6 alkenyl, C3-10 aryl, C4-12 aralkyl; A, B, Y?1, Y2, Z1, Z2, Z3 and Z4¿ may be the same or different and are selected from H, halogen, C¿1-12? alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C4-18 aralkyl, SR?2, OR3, NR4R5, CO¿2R6 and CONR7 2 wherein each R?2, R3 and R4¿ is the same or different and is selected from H, C¿1-12? alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C1-12 alkoyl, C3-12 aryloyl and C4-18 aralkyl, and each R?5, R6 and R7¿ is the same or different and is selected from H, C¿1-12? alkyl, C2-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C4-18 aralkyl; provided that at least one of A and B is OR?3¿, and pharmaceutically acceptable derivatives thereof.