| 摘要 |
<p>Polar lipid formulations of nicotine in liquid crystals and colloidal dispersions thereof and precursors or offspring thereof which when in contact with body fluid and/or by the influence of body temperature, are transformed to a liquid crystal or a mixture of liquid crystals, which functions as a controlled release matrix for nicotine suitable in e.g. smoking cessation and/or replacement therapies. Disclosed compositions of said liquid crystals or dispersions thereof, their precursors or offspring containing nicotine and anti-irritants or a local analgesic, or any combination of these reduce local irritation of nicotine and masks its taste. Applicable routes of administration and devices includes buccal, using chewing gum in which liquid crystals, dispersions thereof, or precursor or offspring thereof are formulated, buccal adhesives, gels and patches, using mucoadhesive liquid crystal, dispersions thereof or precursor thereof, and mouth spray using dispersion of said liquid crystals, their precursors or offspring, nasal spray and gel using said liquid crystals or their dispersions, their precursors or offspring, topical, using said liquid crystal or their precursors or offspring in adhesive patches and gels.</p> |
