Tetrazole compounds and pharmaceutical agents containing such derivative as an active ingredient

摘要

A tetrazole derivatives of formula (I)whereinR1 is H, alkyl, alkoxy, carbocyclic ring, hetero ring, alkyl or alkoxy substituted by carbocyclic ring or hetero ring, etc.; AA1 is bond or AA2 is bond or AA1 and AA2, together, may have the formula (a); Y is the formula (b)(in which Tet ring is tetrazole; Z is alkylene, alkenylene, O, S, SO, SO2, NR26, methylene in alkylene replaced by O, S, -SO-, -SO2- or -NR26-; E is H, alkyl, COOR27 or in which Cyc is carbocyclic ring or hetero ring);a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has a pharmaceutical agents as an active ingredient. The compound of the formula (I) has an inhibitory effect on interleukin-1beta converting enzyme, therefore, they are useful for prevention and/or treatment of various kinds of inflammatory disease.