发明名称 |
A NOVEL SYSTEM FOR THE EVALUATION OF THE ACTIVITY AND/OR SPECIFICITY OF A VIRAL COMPONENT |
摘要 |
The present invention relates to a method for the evaluation of the activity and/or specificity of a regulatory sequence or of a viral component, wherein a viral vector is introduced into a cell of a transgenic non-human animal comprising in its genome one or more viral sequences. However, said transgenic animal is deficient in at least one viral sequence required for generation of the virus. This viral sequence is included in the viral vector introduced into the cell of the transgenic animal, thereby allowing reconstitution of viral particle generation in the transgenic animal. After maintaining the transgenic animal under suitable conditions allowing the production of viral particles, the cells in which viral particles are produced can be detected and evaluated, respectively. The method according to the present invention can also be adapted to evaluate the distribution of a receptor for a ligand in an animal. The present invention also provides a transgenic non-human animal applicable for use in the method according to the present invention. |
申请公布号 |
WO0230471(A2) |
申请公布日期 |
2002.04.18 |
申请号 |
WO2001EP11626 |
申请日期 |
2001.10.08 |
申请人 |
BAVARIAN NORDIC RESEARCH INSTITUTE A/S;AUSTRIAN NORDIC BIOTHERAPEUTICS AG;RENNER, MATTHIAS;GUENZBURG, WALTER |
发明人 |
RENNER, MATTHIAS;GUENZBURG, WALTER |
分类号 |
A01K67/027;A61K48/00;A61K49/00;C07K14/16;C12N15/09;C12N15/85;C12N15/86;C12N15/867;C12Q1/70 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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