| 发明名称 |
Transferrin-Polykation/DNS-Komplexe für die systemische Therapie von Tumorerkrankungen mit zytotoxischen Proteinen |
| 摘要 |
The invention relates to a DNA complex containing at least one DNA molecule and coding for at least one therapeutically effective protein having cytotoxic activity; and a transferrin-conjugated polycation, the zeta potential thereof being </=+15mV. The complex, in which a high proportion of transferrin shields the positive charge, enables therapeutic DNA to be transported to tumours in a targeted manner during the systemic treatment of tumour diseases.
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| 申请公布号 |
DE10049010(A1) |
申请公布日期 |
2002.04.18 |
| 申请号 |
DE20001049010 |
申请日期 |
2000.10.04 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
KIRCHEIS, RALF;WAGNER, ERNST;WIGHTMAN, LIONEL;OSTERMANN, ELINBORG |
| 分类号 |
A61K38/19;A61K48/00;C12N15/12;C12N15/24;C12N15/28;(IPC1-7):C12N15/12;C07H21/00;C07K14/475 |
主分类号 |
A61K38/19 |
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