发明名称 |
Kristallin bas av citalopram |
摘要 |
Crystalline citalopram base as well as citalopram hydrochloride and hydrobromide with a purity above 99.8% (wt./wt.), especially above 99.9% (wt./wt.) are new. Independent claims are also included for: (A) the production of a citalopram salt comprising: (a) liberation of citalopram base and precipitation of the liberated base in crystalline form; (b) optional recrystallisation of the crystalline base; and (c) conversion of the crystalline base into a salt; and (B) the production of citalopram base or a citalopram salt comprising (i) removal of one or more impurities of formula (I) from a crude citalopram mixture or a crude citalopram salt by precipitation of crystalline citalopram base; and (ii) optional recrystallisation and/or conversion into a salt. [Image] Z : halo; -O-SO2-(CF2)n-CF3; -CHO; -NHR1>; -COOR2>; or -CONR2>R3>; n : 0-8; R1>H or alkylcarbonyl; R2> and R3>H; alkyl; optionally substituted aryl; or aralkyl. - ACTIVITY : Antidepressant. - MECHANISM OF ACTION : Serotonin re-uptake inhibitor. |
申请公布号 |
SE517136(C2) |
申请公布日期 |
2002.04.16 |
申请号 |
SE20010003046 |
申请日期 |
2001.09.14 |
申请人 |
H LUNDBECK AS |
发明人 |
HANS *PETERSEN;KLAUS PETER *BOEGESOE;PER *HOLM |
分类号 |
C07D307/87;A61J3/10;A61K9/20;A61K31/00;A61K31/34;A61K31/343;A61P25/00;A61P25/24;C07C209/86;C07C253/14;C07D;C07D307/84;(IPC1-7):C07D307/87 |
主分类号 |
C07D307/87 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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