| 发明名称 |
CHEMOKINE MUTANTS IN THE TREATMENT OF MULTIPLE SCLEROSIS |
| 摘要 |
Mutants of CC chemokines, which contain at least two mutations in the cation ic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/ or other demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.
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| 申请公布号 |
CA2423616(A1) |
申请公布日期 |
2002.04.11 |
| 申请号 |
CA20012423616 |
申请日期 |
2001.10.03 |
| 申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
PROUDFOOT, AMANDA;WELLS, TIMOTHY N.C.;KOSCO-VILBOIS, MARIE |
| 分类号 |
C12N15/09;A61K38/00;A61K38/19;A61P25/00;C07K14/47;C07K14/52;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/19;C12P21/02;(IPC1-7):A61K38/19 |
主分类号 |
C12N15/09 |
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