| 摘要 |
PROBLEM TO BE SOLVED: To provide an antitumor vaccine containing as an active ingredient tumor-associated antigens that characterize tumors of given histologic types, exemplified by CO-029, which is associated with tumors of the gastrointestinal tract, colorectum and pancreas, and by GA-733-2, which is associated with tumors of the gastrointestinal tract, prostate, cervix, ovary, bladder, lung, breast, colorectum and pancreas, while these antigens are broadly shared by these tumors, can be synthetically prepared, independently of the tumor itself, and while these independently prepared antigens are useful as active ingredients in compositions which provide therapeutic protocols to subjects that harbor such tumors or are at risk from such tumors. SOLUTION: The vaccine compositions of the invention have enhanced antigenicity by virtue of encapsulation of these antigens in liposomes or covalent coupling of the antigens with liposomes.
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