发明名称 Derivatives of azetidine and pyrrolidine
摘要 The invention relates to a compound having formula (I) wherein A is an optionally unsaturated 5- or 6-membered ring, which may comprise a heteroatom selected from N, O and S and which may be substituted with oxo or (1-6C)alkyl; R1, R2 and R3 are independently H, (1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkoxy-(1-6C)alkyl, carbo(1-6C)alkoxy or halogen; X is O or S; and n is 1 or 2; or a pharmaceutically acceptable salt thereof, with the exception of 3-(naphth-1-yl-oxy)-pyrrolidin and 3-(5,6,7,8-tetrahydro-napth-1-yl-oxy)-pyrrolidin. The compounds of the invention have antidepressant activity and can be used in treating or preventing serotonin-related diseases.
申请公布号 US2002040016(A1) 申请公布日期 2002.04.04
申请号 US20010870032 申请日期 2001.05.30
申请人 LEYSEN DIRK;WIERINGA JOHANNES HUBERTUS;BROEKKAMP CHRISTOPHORUS LOUIS EDUARD 发明人 LEYSEN DIRK;WIERINGA JOHANNES HUBERTUS;BROEKKAMP CHRISTOPHORUS LOUIS EDUARD
分类号 A61K31/396;A61K31/397;A61K31/40;A61K31/4709;A61K31/4725;A61P3/04;A61P13/02;A61P15/10;A61P25/00;A61P25/04;A61P25/22;A61P25/24;A61P25/30;A61P25/32;A61P43/00;C07D205/04;C07D207/12;C07D401/12;C07D409/12;(IPC1-7):C0741/02;C0743/02;A61K31/470;A61K31/404;A61K31/402 主分类号 A61K31/396
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