| 摘要 |
The invention provides a method of synthesizing a diketopiperazine of the formula: wherein: R1 is -CH2COR3, or -CH2CH2COR3; R2 is the side chain of an amino acid selected from the group consisting of glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, thyroxine, cysteine, methionine, norvaline and onithine; R3 is -OH, -NH2, -OR4, -NHR4, or -NR4R4; and each R4 is independently an alkyl, aryl, alkylaryl, or arylalkyl.
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