发明名称 |
Synthesis of histamine dihydrochloride |
摘要 |
The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
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申请公布号 |
US2002035268(A1) |
申请公布日期 |
2002.03.21 |
申请号 |
US20010974469 |
申请日期 |
2001.10.09 |
申请人 |
YEH WEN-LUNG;ANTCZAK CASIMIR;MCGOLRICK JEFFREY DAVID;ROTH MICHAEL JOSEPH;WRONA MARK |
发明人 |
YEH WEN-LUNG;ANTCZAK CASIMIR;MCGOLRICK JEFFREY DAVID;ROTH MICHAEL JOSEPH;WRONA MARK |
分类号 |
C07D233/64;A61K36/886;C07D;C07D233/54;C07D233/61;(IPC1-7):C07D233/61 |
主分类号 |
C07D233/64 |
代理机构 |
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主权项 |
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地址 |
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