PEPTIDE EPITOPES RECOGNIZED BY ANTIGEN SPECIFIC CD4<+> T LYMPHOCYTES

摘要

The invention provides methods for identifying and validating epitopes that are bound to class II MHC molecules and activate CD4+ T cells involved in the pathogenesis of or protection from diseases, e.g., cancer. The invention includes peptide epitopes (including altered peptide ligands) derived from the CEA polypeptide by such methods, and methods of therapeutic use of these epitopes against diseases such as cancers.