PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS

摘要

This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula (V) wherein Z<1> is N, CR<a>, or CH, and Z<2> is N or CH, provided one of Z<1> and Z<2> is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substitutents independently selected from -R<1>; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R<x> and R<y> are independently selected from T-R<3>, or R<x> and R<y> are taken together with their intervening atoms to form a fused ring; and R<1>, R<2>, R<2'>, R<3>, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.