| 摘要 |
<p>The present invention involves a method of detecting mutant DSPP gene of hereditary opalescent dentin. The invention locates the mutation locus resulting in hereditary opalescent dentin in the third exon of dspp, and describes the application of said method in the diagnosis and therapy of hereditary opalescent dentin cases. Thereby the invention sets the foundation for further studies on the mineralizing process of teeth, nosogenetic mechanism of hereditary opalescent dentin, as well as their utilities in clinic and antenatal diagnosis. The invention also provides a kit and its use in the diagnosis and therapy of patients with hereditary opalescent dentin.</p> |
