| 摘要 |
<p>A selfemulsifiable formulation comprising of lipophilic system consisting of medium chain triglyceride of caprylic acid and capric acid, and of labrasol, wherein labrasol also serves as surfactant, which is combined with other selected surfactants, like cremophore RH 40 and/or polysorbate 80 is disclosed, wherein said formulation also comprises of immunosuppression agent essentially cyclosporine, hydrophilic agent preferably ethanol, antioxidant preferably alpha-tocopherol and preservative preferably benzyl alcohol, and said formulation is prepared by dissolving immunosuppression agent in hydrophilic agent followed by entrapping with lipophilic agent and subsequent treatment with surfactants, preservative and antioxidant, and is filled in soft-gelatine shell capable of rupturing in less than 10 minutes to deliver said formulation in upper part of gastrointestinal tract, wherein it forms thermodynamically stable oil in water microemulsions in situ to have enhanced bioavailability and bioabsorption of immunosuppression agent, which can show its enhanced immunosuppression activities thereby.</p> |
