| 摘要 |
<p>The inventors succeeded in cloning a protein binding to Reg protein from rat pancreatic Langerhans' islet-derived cDNA. It was revealed that the protein expressed on the COS cell surface specifically binds to Reg protein. When the Reg-binding protein is expressed in RINm5F beta cells, DNA synthesis and cell proliferation are stimulated depending on the dose of the Reg protein added to the medium, and at a higher concentration, apoptosis is induced. It is considered that the protein functions as a Reg receptor expressed on the surface of cells such as beta cells and regulates the proliferation of these cells. The protein and gene thereof are useful in developing novel therapeutic agents for diabetes.</p> |
