发明名称 |
VERFAHREN ZUR HERSTELLUNG VON ANTI-MALARIA ARZNEIMITTEL |
摘要 |
The invention relates to novel intermediates and processes for the preparation of quinoline compounds useful as anti-malarial drugs and novel intermediates useful in the process. A process for the preparation of a compound of formula (I) in which R1 is C1-6 alkyl; R2 and R3 are independently hydrogen, halogen, trifluoromethyl or C1-6 alkoxy; R4 is C1-6 alkyl; R5 is hydrogen or C1-6 alkyl; and R6 or amino which comprises reacting a compound of formula (II) in which R1, R4 and R5 are as defined in formula (I) and X is a leading group with a compound of formula (III). |
申请公布号 |
AT214372(T) |
申请公布日期 |
2002.03.15 |
申请号 |
AT19960934646T |
申请日期 |
1996.10.11 |
申请人 |
SMITHKLINE BEECHAM PLC;SMITHKLINE BEECHAM CORPORATION |
发明人 |
UGWUEGBULAM, CLETUS;FOY, JAMES, EDWARD |
分类号 |
C07D215/22;A61K31/00;A61K31/47;A61K31/4706;A61P33/00;A61P33/06;C07D215/227;C07D215/40 |
主分类号 |
C07D215/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|