发明名称 |
DSP-2 DUAL-SPECIFICITY MAP KINASE PHOSPHATASE |
摘要 |
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation of DSP-2 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-2 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
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申请公布号 |
WO0056899(A9) |
申请公布日期 |
2002.03.14 |
申请号 |
WO2000US07589 |
申请日期 |
2000.03.22 |
申请人 |
CEPTYR, INC.;LUCHE, RALF, M.;WEI, BO |
发明人 |
LUCHE, RALF, M.;WEI, BO |
分类号 |
G01N33/50;A61K38/46;A61K39/395;A61K45/00;A61K48/00;A61P3/00;A61P35/00;A61P37/00;A61P37/06;A61P43/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/22;C12N9/16;C12N15/09;C12N15/55;C12P21/08;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C12N15/55;C12N15/11;C12Q1/42 |
主分类号 |
G01N33/50 |
代理机构 |
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地址 |
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