发明名称 |
5-Lipoxygenase gene polymorphisms and their use in classifying patients |
摘要 |
The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.
|
申请公布号 |
US6355434(B1) |
申请公布日期 |
2002.03.12 |
申请号 |
US20000617871 |
申请日期 |
2000.07.17 |
申请人 |
BRIGHAM & WOMEN'S HOSPITAL |
发明人 |
DRAZEN JEFFREY M.;IN KWANG-HO;ASANO KOICHIRO;BEIER DAVID;GROBHOLZ JAMES |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|