PYRROLIDINE DERIVATIVES AND THEIR USE AS CHYMASE INHIBITOR

摘要

Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R<1> is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substituted or unsubstituted indolyl, benzofuryl, substituted or unsubstituted benzothienyl, etc.; R<2> is H, alkyl, phenyl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; R<3> is (i) substituted or unsubstituted monocyclic heterocyclic group, (ii) substituted or unsubstituted, benzene- or pyridine-fused heterocyclic group, or (iii) a group (a): R<4> and R<5> are independently H or OH, but R<4> and R<5> are not simultaneously H, or both form oxo; n is 0, 1, 2 or 3; or a salt thereof.