| 摘要 |
<p>Nucleoside analogs represented by the following general formula (1) and oligonucleotide derivatives containing one or more of the same wherein B represents an aromatic base having carbonyl oxygen at the 2-position or 2-hydroxyphenyl. These oligonucleotide derivatives are triplex-forming oligonucleotide derivatives which, in the antigene strategy, directly bind to a target duplex DNA with a high affinity to form a triplex DNA, thereby efficiently controlling or inhibiting the expression of the gene while showing a high tolerance against nuclease.</p> |
