| 摘要 |
PROBLEM TO BE SOLVED: To provide new means to study, diagnose, prevent and treat inflammation. SOLUTION: DNA sequences encoding endothelial cell-leukocyte adhesion molecules (ELAMs), methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and 1b) substantially free from normally associated animal proteins are disclosed. Antibodies to ELAMs are also disclosed. DNA sequences encoding molecules (MILAs) involved in leukocyte adhesion, method for producing such molecules and MILAs (including the specific molecule, CDX) substantially free from normally associated animal proteins are also disclosed. Antibody preparations which are reactive for MILAs are also disclosed. Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells, and methods for detecting acute inflammation are disclosed. |
