发明名称 |
Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
摘要 |
The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
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申请公布号 |
NZ503402(A) |
申请公布日期 |
2002.03.01 |
申请号 |
NZ19980503402 |
申请日期 |
1998.09.24 |
申请人 |
EPIX MEDICAL, INC |
发明人 |
LAUFFER, RANDALL B;DUNHAM, STEPHEN O |
分类号 |
G01R33/48;A61B5/055;A61K49/00;A61K49/06;A61K49/08;(IPC1-7):A61K49/00 |
主分类号 |
G01R33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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