PROCEDE D'IDENTIFICATION DE SUBSTANCES UTILES POUR LE TRAITEMENT DE L'INFLAMMATION METTANT EN OEUVRE L'ELEMENT DE REPONSE DU RECEPTEUR ROR DU GENE IKBALPHA

摘要

The invention concerns a method for identifying substances useful for treating inflammation, characterised in that it comprises the following steps: (a) contacting said substance with a nucleic acid construct containing the response element to the ROR receptor of the promoter of the I kappa B alpha gene in conditions suitable for allowing said substance to be fixed on the response element; (b) measuring the possible fixing of said substance on the response element or the transcriptional activity of the response element or of a promoter containing it; (c) optionally comparing the measurement of step (b) with a measurement carried out in conditions similar to those of steps (a) and (b) but with a nucleic acid construct non containing the mutated response element.