发明名称 |
USE OF TRILOSTANE AND ITS DERIVATIVES, OPTIONALLY IN COMBINATION WITH TAMOXIFEN OR RALOXIFENE IN THE TREATMENT OF ESTROGEN-DEPENDENT CANCERS E.G. BREAST, PROSTATE AND UTERUS CANCERS |
摘要 |
Use of a compound of formula (I) or a 3-enol C1 to 4 alkanoate ester thereof in the manufacture of a medicament for the treatment of a hormone dependant condition by modulation of the oestrogen receptor beta (ER beta ) wherein R1, R2, R5 and R6 are the same or different and each is hydrogen or C1 to 4 alkyl; R3 is hydrogen, C1 to 4 alkyl, C1 to 4 alkenyl or C1 to 4 alkynyl; R4 is hydroxy, C1 to 4 alkanoyloxy, a group of formula (II) or (III) wherein R7 is (CH2)n, where n is an integer of from 0 to 4, R8 is hydrogen, C1 to 4 alkyl, hydroxy or NH2 and R9 and R10 are the same or different and each is hydrogen or C1 to 4 alkyl; or R3 and R4 together are oxo, ethylenedioxy or propylenedioxy.
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申请公布号 |
WO0153321(A3) |
申请公布日期 |
2002.02.28 |
申请号 |
WO2000GB02858 |
申请日期 |
2000.07.25 |
申请人 |
MARGETTS, GEORGE;PUDDEFOOT, JOHN;VINSON, GAVIN, PAUL |
发明人 |
MARGETTS, GEORGE;PUDDEFOOT, JOHN;VINSON, GAVIN, PAUL |
分类号 |
C07D333/58;A61K31/138;A61K31/4535;A61K31/58;A61K45/00;A61K45/06;A61P5/00;A61P5/32;A61P13/08;A61P35/00;A61P43/00;C07J71/00;(IPC1-7):A61K31/565 |
主分类号 |
C07D333/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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