| 摘要 |
<p>The present invention concerns compounds of the formula (I): (A1)(A2)N-R<1>, the <i>N</i>-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R<1> is substituted C1-6alkyl; -S(=O)-R<8>; -S(=O)2-R<8>; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R<8> being C1-6alkyl, aryl<1> or Het<1>; (A1)(A2)N- is the covalently bonded form of the corresponding intermediate of the formula (A1)(A2)N-H, which is a HIV replication inhibiting pyrimidine of formula (II).</p> |
| 申请人 |
JANSSEN PHARMACEUTICA N.V.;KUKLA, MICHAEL, JOSEPH;LUDOVICI, DONALD, WILLIAM;KAVASH, ROBERT, W.;DE CORTE, BART, LIEVEN, DANIEL;HEERES, JAN;JANSSEN, PAUL, ADRIAAN, JAN;KOYMANS, LUCIEN, MARIA, HENRICUS;DE JONGE, MARC, RENE;VAN AKEN, KOEN, JEANNE, ALFONS;KRIEF, ALAIN |
发明人 |
KUKLA, MICHAEL, JOSEPH;LUDOVICI, DONALD, WILLIAM;KAVASH, ROBERT, W.;DE CORTE, BART, LIEVEN, DANIEL;HEERES, JAN;JANSSEN, PAUL, ADRIAAN, JAN;KOYMANS, LUCIEN, MARIA, HENRICUS;DE JONGE, MARC, RENE;VAN AKEN, KOEN, JEANNE, ALFONS;KRIEF, ALAIN |
