| 摘要 |
<p>An experimental model animal by which type III allergic inflammation can be exclusively evaluated without affected by type I allergy, since it does not suffer from anaphylaxis (i.e., type I allergy) but can specifically undergo an Arthus reaction (i.e., type III allergy); and a method of screening a substance promoting or inhibiting a type III allergic reaction mediated by Fc?RIII by using this experimental model animal. To eliminate Fc?RIIB exerting an inhibitory effect on the Fc?RIII-mediated response, a mouse (LynIIB) carrying deletion mutations of Lyn and Fc?RIII as a homozygote is constructed by crossing a Lyn-knockout mouse (Lyn?-/-¿) and an Fc?RIIB-knockout mouse (Fc?RIIB?-/-¿). Thus, the defect in the FcηRIII function in systemic passive anaphylaxis, lessening in the Fc?RIII function in bone marrow-origin mast cells, etc. are measured and evaluated.</p> |
