发明名称 Quinoline derivatives.
摘要 The invention relates to compounds of general formula (I) wherein R is selected from ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R4 is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R5 is selected from methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, CF3, and OCHxFy; wherein x = 0 - 2, y = 1 - 3 with the proviso that x + y = 3; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods of treating mammals suffering from diseases resulting from autommunity and pathological inflammation by administrering a compound having formula (I) to said mammal.
申请公布号 ZA200004601(B) 申请公布日期 2002.02.27
申请号 ZA20000004601 申请日期 2000.09.01
申请人 ACTIVE BIOTECH AB. 发明人 ANDERS BJOERK;STIG JOENSSON;TOMAS FEX;GUNNAR HEDLUND
分类号 C07D215/56;A61K31/47;A61K31/4704;A61P1/00;A61P3/10;A61P9/10;A61P11/00;A61P11/06;A61P17/06;A61P25/00;A61P25/28;A61P29/00;A61P37/00;A61P43/00;C07D215/22;C07D491/056 主分类号 C07D215/56
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