发明名称 |
Chimeric human-type vascular endothelial cell growth factor |
摘要 |
An object of the present invention is to provide a chimera VEGF-E having a reduced antigenicity while maintaining the activity of VEGF-E. The present invention provides a chimera protein having an activity of growing vascular endothelial cells, which is obtained by substituting a part of the sequence of a VEGF analogous protein having an activity of vascularization that binds to KDR (VEGF receptor-2) but does not bind to Flt-1 (VEGF receptor-1) with a corresponding sequence of a human-derived VEGF analogous protein. |
申请公布号 |
AU7773301(A) |
申请公布日期 |
2002.02.25 |
申请号 |
AU20010077733 |
申请日期 |
2001.08.09 |
申请人 |
CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY INCUBATION, LTD. |
发明人 |
MASABUMI SHIBUYA |
分类号 |
A61K38/00;A61K48/00;A61P9/00;A61P9/10;C07K14/475;C07K14/52;C12N1/15;C12N1/19;C12N1/21;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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